December 1, 2023


Healthy Always

Sure intestine microbes could also be linked to skeletal well being

3 min read

There may be rising proof {that a} relative abundance of sure intestine microbes could also be associated to skeletal well being, based on a brand new examine revealed in Frontiers in Endocrinology. If confirmed by extra analysis, the findings might present the chance to change intestine microbiomes to realize higher bone well being, as scientists study extra about “osteomicrobiology,” a brand new time period not too long ago used to characterize this relationship.

Because of the lack of large-scale human research of the intestine microbiome and skeletal well being, researchers led by Paul C. Okoro, Information Scientist II at Hebrew SeniorLife and Hinda and Arthur Marcus Institute for Growing older Analysis, and principal investigator Douglas P. Kiel, M.D., M.P.H., Senior Scientist on the Marcus Institute, carried out an observational examine primarily based on the Framingham Third Technology Research of women and men, and the Osteoporotic fractures in Males (MrOS) examine of older males to find out whether or not they might discover a doubtlessly modifiable issue contributing to skeletal well being. The examine used high-resolution imaging of the arm and leg.

That is vital as a result of low bone density will increase the chance of growing osteoporosis, affecting greater than 10 million Individuals over the age of fifty, and might improve the chance of fractures.

Entitled “A Two-Cohort Research on the Affiliation between the Intestine Microbiota and Bone Density, Microarchitecture, and Energy,” the examine discovered that micro organism known as Akkermansia, which has been related to weight problems, and Clostridiales bacterium DTU089, had unfavourable associations with bone well being for older adults. DTU089, a bacterium from the category, Clostridia, has been described to be extra considerable in individuals with decrease bodily exercise, and decrease protein consumption, and might be vital as a result of prior research have discovered protein consumption and bodily exercise have a particular connection to skeletal well being.

We discovered patterns through which larger abundance of microbiota had been related to worse measures of bone density and microarchitecture. In actual fact, some micro organism had been related to variations within the bone cross sectional space, suggesting the likelihood that sure microbes might affect how the bone adjustments dimension with ageing. It’s untimely to know if the bacterial organisms themselves could have an affect on skeletal well being. With extra research we’d have the ability to acquire insights concerning associations between particular bacterial species within the gut and skeletal integrity. We additionally hope to determine particular purposeful pathways influenced by the micro organism that would affect the skeleton. For instance, some micro organism can result in low ranges of irritation which will have an effect on bone well being. Finally, if findings like this are confirmed, we might be able to goal the intestine microbiome to affect skeletal well being.”

Dr. Douglas P. Kiel, M.D., M.P.H., Senior Scientist on the Marcus Institute

Harvard T.H Chan Faculty of Public Well being, Oregon Well being and Sciences College, BIDMC, Minneapolis and Palo Alto VA Well being Care System, College of Minnesota, College of Pittsburgh, Stanford College, and Emory College collaborated on this retrospective cohort examine.


Journal reference:

Okoro, P. C., et al. (2023) A two-cohort examine on the affiliation between the intestine microbiota and bone density, microarchitecture, and energy. Frontiers in Endocrinology.

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